Tranny Hole Share definition Flag A male to female post operative 'Vagina'The most vile place a man can visit Friend 1. "I slept with thus chick from the bar last night and I can't shake this feeling of overwhelming shame Friend 2. "Sounds like you screwed a Tranny Hole" " Tranny Hole by Mrs Party Train January 14, 2013 Get the Tranny Hole mug.