In Star Trek it is the General Order 1 of the Starfleet and an oath every Starfleet Personnel has to take and uphold, even if it means death to them or their crew.

As the right of each sentient species to live in accordance with its normal cultural evolution is considered sacred, no Starfleet personnel, Federation citizen and/or representative may interfere with the normal and healthy development of alien life and culture. Such interference includes introducing superior knowledge, strength, or technology to a world whose society is incapable of handling such advantages wisely. Starfleet personnel may not violate this Prime Directive, even to save their lives and/or their ship/installation, unless they are acting to right an earlier violation or an accidental contamination of said culture. This directive takes precedence over any and all other considerations, and carries with it the highest moral obligation.

The Prime Directive is overridden by:
* Omega Directive (Top Secret)
* General Order 24

Furthermore, Federation Citizens are not bound to the Prime Directive.
The Prime Directive is not just a set of rules; it is a philosophy... and a very correct one. History has proven again and again that whenever mankind interferes with a less developed civilization, no matter how well intentioned that interference may be, the results are invariably disastrous. --Jean-Luc Picard, 2364

Someday my people are going to come up with some sort of a doctrine, something that tells us what we can and can't do out here; should and shouldn't do. But until somebody tells me that they've drafted that... directive... I'm going to have to remind myself every day that we didn't come out here to play God. --Captain Jonathan Archer, 2151
by Aendaeron May 2, 2016
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The Prime Directive of the male species is to fuck bitches and get money
Josh: Adam, what’s our prime directive??
Adam: Come on josh, everyone knows this. Our Prime Directive is to fuck bitches and get money
by Spray cheese January 2, 2019
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something on Star Trek ... if you know the full answer ... you live with your mom and don't have a girlfriend ...

oh and you probably eat food from 7-11
person 1 "well on star trek they had the prime directive"

person 2 (female) "i'm going to go stand over there now"

person 1 (weeps softly)
by some music snob April 22, 2005
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Term used in Academic Team (don't laugh) where one team buzzes in early on a question and gets it wrong so the question is to be read in it's entirety to the other team. No one player on this team should buzz in early while the question is being read. Doing so will result in "Prime Directive," and angry stares from your teamates because you were supposed to wait until they knew what it was (jealous little shits).

I commit Prime Directive all the time because I am a power hungry Indian male and thats that's what Power Hungry Indian males do. It doesn't really matter because I always get the question right so get off my case, John!
John: Man, Kush! That's your third Prime Directive this tournament, you gotta learn to wait!
Kush: Shut the fuck up bitch, that's three more toss ups than you've scored.
by Agra March 31, 2004
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When you fap over the moral implications of an action.
Man, I totally had a prime directive fap when I was trying to decide whether or not to tell my boyfriend I spent all our savings on a model Enterprise.
by Moghidean September 9, 2011
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