Pheemale Share definition Flag 1. (Noun) An alternative word for "female" used to make the acronym pff work to describe a group of girls' fat friend. pff = pheemale fat friend. 1. Damn, those hot chicks have more than one pff (pheemale fat friend). Pheemale by .,Dan,. July 26, 2005 0 0 Get merch Get the Pheemale mug. Buy Now — $32.95 See more merch