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The physical, mental, and emotional condition one achieves through prolonged periods (generally multiple consecutive days) of sleep deprivation, malnutrition, & dehydration while under the influence of methamphetamines. Symptoms vary among individual users. However, common effects are delirium, schizophrenia, irritability, anxiety, mood swings, irrational & compulsive dis-assembly of household appliances & devices, chronic back & neck misalignment, and ill-advised barter of personal possessions (not necessarily belonging to the one affected by the condition).
The scatter-brained tweaker was obviously on a good one as he carpet surfed his car & sifted through the vacuum bag for meth on day five.
by Llenar13 January 30, 2010
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the same as on one but for a longer period of time. i.e. five or more days.
He would have outran the cops but he was on a good one and it finally caught up with him.
by brandon's wife May 21, 2004
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To be sexually stimulated to the point you want to have sex.

When the penis gets hard from a male thinking dirty thoughts and this make him want to fuck. The vagina hardens when a female thinks naughty and this makes her want to fuck.
Say whodie, my girl had me on a good one last night.

Girl my boyfriend had me on a good one earlier today when we were on the phone.
by Kietee025 June 25, 2006
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