On a Good One 

The physical, mental, and emotional condition one achieves through prolonged periods (generally multiple consecutive days) of sleep deprivation, malnutrition, & dehydration while under the influence of methamphetamines. Symptoms vary among individual users. However, common effects are delirium, schizophrenia, irritability, anxiety, mood swings, irrational & compulsive dis-assembly of household appliances & devices, chronic back & neck misalignment, and ill-advised barter of personal possessions (not necessarily belonging to the one affected by the condition).

The scatter-brained tweaker was obviously on a good one as he carpet surfed his car & sifted through the vacuum bag for meth on day five.

On a Good One by Llenar13 January 30, 2010

on a good one 

the same as on one but for a longer period of time. i.e. five or more days.

He would have outran the cops but he was on a good one and it finally caught up with him.

on a good one by brandon's wife May 21, 2004

on a good one 

to be really hyperactive usually enhanced by stimulants (caffeine, sugar, chocolate)

lil monster is on a good one

on a good one by skaterjack October 5, 2006

On a good one 

To be sexually stimulated to the point you want to have sex.

When the penis gets hard from a male thinking dirty thoughts and this make him want to fuck. The vagina hardens when a female thinks naughty and this makes her want to fuck.

Say whodie, my girl had me on a good one last night.

Girl my boyfriend had me on a good one earlier today when we were on the phone.

On a good one by Kietee025 June 25, 2006