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Short for Hermano, which means brother in Spanish.
Hey, you want a cold beer mano?
by Egyptian Magician June 30, 2005
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Nov 27 Word of the Day
A stupid person; it refers to the lack of surface area on an individual's brain. The general thought is that the more surface area (wrinkles, creases, etc.) a brain has, the smarter the person is. Conversely, a person with a smooth brain (no wrinkles) has less surface area and would therefore be stupid.
That fucking smooth brain put his shirt on backwards again...

That smooth brain is dumber than a pile of shit.
by Tip Tank May 14, 2011
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2
is a slang for irmão, which means brother in Portuguese.
hey mano let's pick up some chicks
by sacht March 11, 2014
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4
Slang for good friend or person you have known a while and bonded with ( Mano - male ) ( mana - female ) originated from the Spanish slang of hermano (brother) someone you are close to. Popular between 2 people that originate from seperate countries. I.e Britain and Spain
Hey, Mano!

Hey!
by ENG.DICT July 08, 2012
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5
23:11 <Manos> The last time I had pussy, it was awesome.
23:12 <willyg> yea
23:12 <Manos> This was YESTERDAY.
23:12 <willyg> it always is
23:12 <electronarcosis> cool
23:12 <Manos> And it was with 3 different women.
by mancharmer June 29, 2009
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6
odd, weird, out of the norm, creepy, mysterious, outlandish, ridiculous, and unusual; something seen as being in "the hands of fate." As made popular by MST3K.
"The other day, on a whim, my friends and I decided to kill a goat. We used a rock and it took eight tries. It sounded fun at first, but turned out to be manos."

by Thel200ster March 18, 2007
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