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mdo is a suffix meaning "my dick off." It is used by appending the first letter of a gerund in order to create an acronym that signifies one is going all out to complete a task. It works on the basis of hyperbole by stating that one is working so hard on something that it somehow causes their dick to fall off.
Possible uses could include:

wmdo = writing my dick off
pmdo = presenting my dick off/proofreading my dick off/partying my dick off
amdo = animating my dick off
smdo = sleeping my dick off

...With infinite possibilities
mdo by Friar Sloth November 7, 2010
Related Words
mdot MDO mdof MDOH Mdoko mdom mdonel MDORAHWBy Mdosi Mdot 59
short description for 'more day old.'

1. Used to describe when something is out of fashion.

2. When you are totally completely over something.
MDO by bgrizzly July 1, 2009
MDO by Anonymous October 28, 2003
Modern Day Outlaws; A splendid TFC clan led by Helix. MDO ranked 3rd in the Iron Division of the UGC League in Season 3.
"i hate MDO they always fucking kill me"
MDO by ... September 30, 2003
MDO by Anonymous November 9, 2003
A person who gets so drunk at home and ruins friendsgiving. Someone who doesn’t leave their house to have beers with the boys unless it’s at their house. Someone who has to be babysat
I was supposed to hang with the fellas tonight but pulled a Mdo
Mdo by Dump n change podcast October 14, 2020