A word-mix of "ker-plop", "fuck-up", and "fumble", meaning:
1) A huge mistake or poor
decision made by a dumbass.
2) A person guilty of such
dumbassery that the word is applied
directly to him/her.
1) *Our dumbass
president makes another stupid
decision* "Well, that was a kerfuckle of a move."
2) *
Dumbassery is commited* "Dude, you are such a king-sized kerfuckle."