I don't give two and a half shits 

You really, REALLY don't care about what someone just told you.

Brody: Hey, I just found this really funny video I wanna show you, it's about this-

Ryan: I don't GIVE two and a half shits, alright?!

I don't give two and a half shits by MCGONN June 17, 2009

I don't give two and a half shits 

Combining a reference to two and a half men and the fact that you care so little about what the other person's saying.

-Hey, guess what I was doing last night?
-You know what? I don't give two and a half shits!

I don't give two and a half shits by Deathgleaner May 24, 2010