Derived from the Warhammer and Warhammer 40,000 universes, Humie is often used by the Orks to refer to Humans, (Imperial Guard or Space Marines). It is not necessarily in a derogatory tone but being orks, it usually is.

This may also be employed by ork fans in other fantasy or sci-fi games where Orks / Orcs are a playable race along with Humans, such as World of Warcraft, (though officially in the lore, WoW Orcs do not really talk like that).

When you eat dirt for the first time and leave your family to build a shack in the woods

A human being. Used sometimes in World of Warcraft by other races, as a derogatory term.

A derogatory term for a human being. Especially used by extraterrestrials.

a combination of "homie" and "honey" used for your best friend in a funny non sexual way

1. n. Like "homie," only, ten billion times nerdier. Almost as nerdy as a humanities student calling another his or her "homie," not that s/he would ever do that, because they have refined it to be "humie." Thusly, I give you the glories that are.... HUMIES.