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Horny Syndrome disease is a disease first discovered by Dr. Ulaganathan during his studies in Ireland. It is characterised by Priapism, sweating, increased heart rate and increased rate of breathing.
Fuck me man, that girl over there is causing a flare up of my HSD
by Hilly420 November 13, 2018
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Aug 11 Word of the Day
You can tell by the way she walks, she got that WAP.

You can look at her face and tell she ain't got that WAP.
by Black Don August 06, 2020
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2
an acronym, commonly used on the Internet, meaning "holy shit, dude", derived from the infamous South Park feature film, 'South Park: Bigger, Longer, & Uncut' quote - Kyle Broflovski
Mr. Garrison: What did you say?!
Eric Cartman: Oh, I'm sorry, I'm sorry. What I said was: How would you like to SUCK MY BALLS, Mr. Garrison?
Kyle Broflovski: Holy shit, dude(HSD)...
by BenJAMSTER July 10, 2008
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3
High Sex Drive.
Normally owned by males who masturbate to much. Can end in death of their girlfriend.
Unless the girl has it too...
Boy: Come here, *Grunts* Ooooh more.
Girl: Fuck stop that hurts!
Boy: You like it!
Girl: Stop! You have HSD...
by GeeHSDx September 07, 2008
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Acronym for 'hardcore street drugs'. Usually means heroin, crack, meth, etc.
by slsanity August 24, 2013
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Holy Snapping Duck Shit - an exclamation of total surprise.
Holy snapping duck shit! When I posted hsds I didn't mean Hardcore Satan Death Sex
by JMannus May 02, 2011
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