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Fuck's up? 

1.) A more refined way of saying "What the fuck is up?"

2.) A common Michigander greeting.
Fred: Hey Bitch. Fuck's up?
Sally: Not too much.
Fuck's up? by BSliggs June 29, 2011

Fuck's up? 

A different variation of a widely used term,"What's up?"
Person 1: Hey, John.

Person 2: Fuck's up?
Person 1: Not much.
Person 2: Cool, real cool...

Fuck's That? 

Commonly used phrase by (Fatchew) when confused about anything.
Sombody walks into a room.

Fucks That?
Fuck's That? by Clareol July 19, 2003

Fuck's Cunt 

a statement used when something takes you by surprise and pisses you off at the same time usually followed by absconding the person who offended you.
on the subject of a man sampling his own fluid:

Steve: Dude, its not gay if its your own.

Bill: What in Fuck's Cunt are you talking about??? Get out of my house!!!!!
Fuck's Cunt by King Leper September 22, 2010

Fuck's Santorum 

Pretty much means Dan Savage's "santorum," but with the "fuck" having possession.

Used as "What in Fuck's Santorum" or "Why in Fuck's Santorum?" Like, "What in Jesus' name?"
"What in fuck's santorum is a 'gender-reveal party' and why in fuck's santorum would anyone care?"
Fuck's Santorum by Brash Lion September 24, 2012

Fuck's Fire 

A phrase used when one is extremely confused or angry.
Man 1 playing Halo:You just got killed by that guy.
Man 2 playing Halo:I don't know where in fuck's fire he came from.