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Simply, FTFO means "Fight the Fuck On." It's a play off the Trojan phrase "Fight On," but gives it more of a kick (even though Trojans always go hard, it's just assumed they all Fight the Fuck On.)
We beat the bRuins 50-0! FTFO!
by TrojanForLife January 29, 2012
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Flip The Fuck Out. Describes someone losing their cool, going apeshit, out of control.
The boyfriend F.T.F.O. after catching his girl in bed with another girl.
by JazzyJuggs November 13, 2006
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1. An abreviation for FTFO
2. A CD by Shaggy 2 Dope from ICP
"This shit ain't for pussy heads (So fuck off)
This ain't for you rookie kids (FTFO)
Bloody creatures carve your head out (So fuck off)
This the shit that brings the dead out (FTFO)"
-Shaggy 2 Dope
by Selice August 29, 2006
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