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Unlike Down Syndrome which causes a person suffering from it to have below average intelligence amongst other physical flaws, Bottom Syndrome causes a person suffering from it to be as stupid as humanly possible.
Mike: Man, john is just such a retard! does he have down-syndrome?

Richard: Actually, he's too stupid to have Down syndrome, i think he might have Bottom Syndrome.
by Fruitfly February 16, 2012
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