The pathological cell type identified in Bushcle-Lowenstein tumors. Buschle-lowenstein tumors are a rare benign penile tumor caused by human papilloma virus infection with giant tumor growth but only local tissue destruction; may result in urethral fistula formation. The tumor resembles a cauliflower-like mass. Diagnosis is achieved via collecting cell scrapings of the mass with subsequent identification of motherfucking cells (MFCs) on diagnostic electron microscopy. There has been considerable debate regarding the exact nature, etiology, and treatment of these lesions. Like oral florid papillomatosis and epithelioma cuniculatum, Buschle-lowenstein tumors are considered to be a regional variant of verrucous carcinoma. MFCs have been observed on samples involving the penis, vulva, scrotum, bladder, and perianal or anorectal regions. Management of these tumors is controversial, but involves chemotherapy, radiation, and surgery.
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