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To have a retarded face, or expression causing others to find it funny, creepy or just plain stupid.
Ex. 1 Jennifer Lawrence is the queen of derp because of the faces she makes.

Ex. 2 "I'm bored."
"Me too."
*Awkward silence.*
"Derp."
"Yeah..."

Ex. 3 Jennifer Lawrence Queen of Derp trended on Twitter worldwide. (FACT)
Derp by Swim-on-and-on-and-on.... October 3, 2012
Related Words
derp Derpy Derping derpes Derper Derped Derpin derpression derp-derp Derpa
The vocal sound to describe a act of dumb, or a view/image of dumb, seen as a meme, and used on image boards(websites unlisted for certain reasons).
derp!
Derp by Crausy December 31, 2010
An incurable disease, at least until the introduction of Duck Sauce's "Barbra Streisand" with a combination of yelling "Unf Unf Unf" between two mirrors.
Kindoflike Bloody Mary three times, but this one actually works. 50% of the time.

It is known to afflict a certain Jason Liu's face constantly (See "Jason Liu" for more information)

Commonly associated with "Herp"
DocMo: "Hi what's your name?"
Jason: "Derp"
DocMo: "Barbra Streisand"
Kenja: "UNFUNFUNF"
derp by kendaninjabinja May 25, 2011
A person who may catch you while you're doing something that you're not supposed to be doing.
Derp by MSTJ September 27, 2010
Derp- a caption used on silly pictures such as memes.

A word to say after saying something stupid, or derpy.
A word meaning stupid.
Me: "Did u know that butter is a vegtable!?!"
Hater: "No it not you derp!"
Me: "oh, ok"
DERP by TheAllyDerp March 19, 2014
See also herp:

Derp is a word that can replace anything in a sentence. It is somewhat of an everyword, such as fuck. Derp is most commonly used in le rage comics.
"Yo Derphina"
"Lets go to the herp n Derp"
"you look so derpy"
Derp by Zombies<3 October 23, 2011