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little sister

the most annoying little losers in the world who look up to you and wont stop leaving you the fuck alone!
little sister follows you tell her to fuck off, wont stop tell parents older sibling gets blame.
by J'aDoRe JUiiCY September 26, 2006
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When you do or say something that makes you seem retarded. From the Hallmark Hall of Fame movie of the same name starring Rosie O'Donnell in which she plays a "challenged" person who, surprisingly, rides the bus with her sister. What could have been a touching portrayal was ruined by the fact that she spent the majority of the movie screaming and acting like an insane monkey rather than a noble portrayal of a person with mental handicaps. So really, you are acting more like an insane monkey than a retarded person. Can be shortened to Riding the Bus.
"Do you really think you should wear leggings under your skirt? It's a little Riding the Bus with My Sister."

or

"Don't talk so loud in the movie theater. It makes you too Riding the Bus With My Sister."
by The Carester September 26, 2005
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Sister

Sorry, I can't go to that party tonight. I'd rather chill with my sister.
by RaptorMerewolf July 18, 2015
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sister

1. a female sibling

2. a female friend that acts like, loves you like, and treats you like a sibling.
I don't have any sisters.

My best friend is like a sister to me.
by King's Daughter June 29, 2005
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Sister

A Sibling of the Female sex, whom's goal is to create complete hell for the older sibling.
by Sirius July 7, 2003
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Little Sister

the victim of an over protective male influence known as a "big daddy"
Zaxq: poor shelbie has turned into a little sister!
Drew: I Know kyle's being such a big daddy!
by xXPyramidheadXx3 February 17, 2010
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sister-wife

A female (family member/friend), who is a sister (or like a sister), who helps (usually another female) frequently with cleaning, cooking, childcare, other household duties, etc.

There is no romantic involvement with a sister-wife or her spouse, however she is beloved by the whole family.
Heather is always helping me cook, bake, clean and my children love her too! She is my sister-wife!
by Martha2010 November 23, 2009
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