A game residents of Terre Haute, Indiana play while driving through town. When you see someone you have to ask other people in the car, “Is that a tweaker?”. If you just guess yes, you are likely to be correct 75% of the time.
Turn on Locust Street, go a few blocks and when Donnie yells, “Is that a tweaker?” you’re in the right place.

What is that guy doing? Is that a tweaker?
by HairyGinger May 3, 2022
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An invention or solution to a problem while the creator/inventor was high on Methamphetamine
I can’t believe that worked it sure was tweakerative
by Bigmike13 March 29, 2022
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Someone who tinkers and adjust the setting of any object to make them perfect for their own purposes at that particular moment
Bob is such a tweaker. He turned the vacuum cleaner into a tape recorder.
by Pimpsnho's September 22, 2020
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You can see a lot of these in Eugene Oregon . All though the true definition of tweaker is someone on meth but people can be on be tweakers with out meth sometime just weed and or alcohol. You will see most these people that non meth tweakers at night they smell like weed and dog shit and don’t listen to their papa. Common other name for tweaker is MILA( musty in lethal wAys)
Dang that girl with a big light up sword running around in a cemetery is a tweaker she looks stinky
by Lordoflandsinegpyt September 21, 2023
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The reason high school security doesn’t go in the boys bathroom anymore, theres always atleast one of them.
Guy 1 “Guys, Jack’s a tweaker,”

Guy 2 “Yeah, we know,”

Guy 3 “He tried to choke me…”

Guy 2 “Okay, thats where we stop talking,”
by Veeve June 7, 2023
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Someone using Crystal meth or ice are referred to as tweakers. They are commonly referred to as tweaking out as in a state of paranoia or moving and twitching profusely.
Look at the tweakers peeking out of the blinds.

Look ! That tweakers been down this aisle 17 times in 2 minutes.
by MizzuzKotzz×3 September 17, 2018
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1. A person that's like a hoe

2. Some one who will talk to alot of females/males at once

3. Some one who's addicted to drugs
"Yo, you a tweaker for real"

"shut up tweaker!!"
by Philly Girl_14 June 20, 2009
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