A disease caught by picking up too many cards in UNO when playing by the rule "Pick up until you can put down" when needing a card.
Michael:"I Change colour to Blue"
Nick: "Darn."
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
John: "Oh damn."
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Ash: Bro he's got Pick-up-till-put-down Syndrome!
Nick: (picks up card)
Nick: Finall-wait nevermind.
Nick: "Darn."
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
John: "Oh damn."
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Ash: Bro he's got Pick-up-till-put-down Syndrome!
Nick: (picks up card)
Nick: Finall-wait nevermind.
by NinjaSlayer_936 January 1, 2021

When you're a regular consumer of nicotine pouches and then run out, you may suffer from Down Zyndrome.
Symptoms are similar to nicotine withdrawals and often include irritability, hunger, anxiety, etc.
Symptoms are similar to nicotine withdrawals and often include irritability, hunger, anxiety, etc.
by BO-G-ART May 15, 2024

by Down Bad April 13, 2021

by Arminkshipper June 20, 2025

by ogoiD February 24, 2023

1) Use of insider information in Australia to get something
2) Handshake with a cock (see also Handjob, Handie, Handjo,...)
2) Handshake with a cock (see also Handjob, Handie, Handjo,...)
"Use your down-unda-handshake to get us the information."
"I received a down-unda-handshake from that chick we met last week in Melbourne."
"I received a down-unda-handshake from that chick we met last week in Melbourne."
by AUtacobender January 18, 2014

by Onte Da LoverBoy February 4, 2024
