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Duff

The shake at the bottom of a bag of drugs, including the seeds and stems in a bag of weed. Commonly used to describe the shake at the bottom of a bag of crystal meth.
Jeff: Hey, let me get a ball of that fire ice. Dan: All I have left is the duff, bro.
by jlthomas110880 November 25, 2020
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Up the duff

An old Australian Slang term referring to an unplanned pregnancy, first used in 1941 and all the way through to around the 70s. Rarely used now a days.
Person 1: What is happening to her?
Person 2: She's up the duff.
by Shen Bapri March 23, 2023
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Duff

A person who doesn't do anything productive with their life after high school - no job, no school, just vibes. Can also describe the act of being unproductive or lazy in general. The word originated from the last name Duffey, a kid who famously did absolutely nothing post-graduation.
Used as a noun:
"Don't be a duff — at least try to apply somewhere."
Used as a verb:
"I was just duffin' it all weekend, didn't move off the couch once."
"He's been duffing his life away since senior year."
Used as an adjective:
"That's the most duff thing l've ever seen — unemployed and still
Lplaining."
by Duffer555 July 21, 2025
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Duff

Designated-ugly-fugly-friend
The one friend in the group who doesn’t really feel like a friend Becuase of how irrelevant they are or feel and when in public is the one who gets asked for the phone numbers of the other attractive friends.
“Yoo you see those hella fine girls man”

“ yes sir I do”

“Go see if you can get their numbers
“ nahh I’m too pussy”
“Oh fairs, jus go ask the DUFF then, their there for a reason”
by Doorknobsontoast_420 July 11, 2020
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duff

The stuff left on the bottom of your weed bags. All the stems, crystals, and leafs. Often used as a cheaper alternative to buds in baking. Though often mistaken as good, and used in joints and bowls. Known to be sold for as cheap as 30-40 dollars an ounce.
Hey bro, got any of that duff? I need to make another's batch of weed brownies.
by fitzy_keegs January 13, 2017
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Duff

1. Designated Ugly Fat Friend
2. A more polite way of saying ass or butt
1. She's such a Duff
2. My Mom always tells me to get off my duff and go outside
by SauceMilliken July 31, 2017
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orange duffe

When you have to take a dump right after eating a huge bag of cheetos. Doritos and other orange texturized flavored chips do not count. You should only use the term when the situation is cheetos, not anything else. Spelling doesnt matter as long as its used in the correct context.
After you eat a big bag of cheetos you tell your buddy that youl just be a second, you go the bathroom and realize this might take a while that was a realy big bag of cheetos. For the first time ever youve come to the conclusion you have reached your limit and take a huge dump, the result... an orange duffe.
by od man December 9, 2007
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