Duff

A blonde chicks vagina.

"Hillary's duff"
"Go get you some of that duff over there"
"I bet that chick has a nice duff"

by Fagboyslim88 January 13, 2017

duff sack

a duffle bag filled with illegal substances usually marijuana

I dropped my whole paycheck on a duff sack of that icky sticky leaf

by flash gordon9989 March 12, 2009

duff

dam ugly fucking friend

that girl is a duff

by mariodros September 7, 2017

Duff

“Designated ugly fat friend”

“Your literally a duff..”

by Goaty_boaty September 18, 2021

DUFF

It is a word you use for that one friend that you don't like. It means DESIGNATED UGLY FAT FRIEND

Kim: Ugh why is she always hanging around us
Nicki: Yeah she's just a DUFF

by Golden_Goddess February 11, 2015

puff duff

When you have too much fun (read: alcohol) and you're lame the next day and stay in bed and not participate in vacation activities.

In Jamaica, Jim partied too hard and the next day stayed in and was a total puff duff.

by CurtisCam1 April 19, 2018

Duff

Designated Ugly Fat Friend

That girl is our duff

by confident black girl January 28, 2015