The act of throwing something or something out a window.

Also the stupidest English word that exists.
by TheCrazyCrafter23 October 21, 2019
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To quickly close a computer window so as to prevent your boss/girlfriend/etc. from seeing it.
I was checking out some hot girl on girl porn on the internet when my girl suddenly came home and I had to defenestrate it right quick.
by Windoze XP March 25, 2005
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The act of throwing someone or something out of a window.
Helga: "What did you just do Bobby?!"
Bobby: "What can't I defenestrate my trash out on to the highway?"
Helga: "Are you retarded?! That's called littering, we could be fined!"
(Cue the police)
by Painthetownfred February 2, 2010
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the defensive act of castrating someone in order to prevent sexual advances. First used in Questionable Content comic number 36.
I had to defenestrate my roommate before he tried to sleep with me.
by RoblingRobot November 10, 2009
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the act of throwing up out the window while drunk.
I was so drunk on Friday night I defenstrated out the cab window.
by Holly October 11, 2004
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1. The act of surpassing sexual goals in such a manner that they have been thrown out a window.
After having had 12 orgasms in 3 hours, she set a goal of 42 orgasms in 24 hours only to commit almighty defenestration by having 50 orgasms in 3 hours.
by Rikkitikki128 June 17, 2017
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The act of being hogtied, gutted, and thrown from a window.

ORIGIN From the Latin roots Lubricus, Reus, Defenestra
Wow, did I actually see a real world application of lubrireus-defenestration? Crazy!

Alternatively:

Hannibal pulled some serious lubrireus-defenestration on inspector Pazzi's ass.
by Latinman! April 12, 2009
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