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To get outclassed, outmatched, and ultimately defeated by their opponents with no chance of winning (typically used in competitive aspects i.e. sports)
Man, the lakers got absolutely skunked by the knicks.
Skunked by awesomeness7575 May 1, 2023
That guy is severely skunked right now
Skunked by olasdagaert January 22, 2024
When you get sprayed by a skunk.
"The reason I smell so bad is because I got skunked."
skunked by SomeCaliGirl April 2, 2024
to get high, usually from smoking weed; being intoxicated or stoned
"Dude let's get skunked."
"I'm so fucking skunked right now."
skunked by Juizys March 5, 2026

Skunked. 

Cockblocked. When the humans are against the aliens and the aliens can't even get through 1 round. A man then says "skunked", a ship explodes, and the aliens die.
guy: skunked.
aliens: Blarrrr
Skunked. by BBJ69 March 6, 2011

Skunked a creamer 

Flatulation that causes the expulsion of semen that was acquired during anal sex.
Luckily I decided to wear panties to brunch because I just skunked a creamer.
Skunked a creamer by Gretchen0.0 November 3, 2017