Duff

Beer you wish you could have but never will.

I'm craving some duff right now bro.

by lemonberrypie August 4, 2017

duff

dumb ugly fat friend

"cant she see she is the duff"

by go to bed April 19, 2017

Duff

dumb ugly or fat friend...

Becky invited her duff so she doesnt get wasted and blows any willing cock within sucking distance

by NorCal Slanger March 27, 2017

Duff

Knock someone clean out

Imma duff his dumbass

by Hatehatty6 March 8, 2020

DUFF

It is a word you use for that one friend that you don't like. It means DESIGNATED UGLY FAT FRIEND

Kim: Ugh why is she always hanging around us
Nicki: Yeah she's just a DUFF

by Golden_Goddess February 11, 2015

Duff

Duff is a quiet man when you first meet him yet is incredibly observant and always listening. He takes his time in both thoughts and actions, but in the end is always ready to share the very best of himself. Duff is strong yet gentle, firm yet kind and mushy. If you are lucky enough to have a Duff in your life, then you are guaranteed a funny and generous confidante who will be by your side forever.

You know it's going to be a great night, Duff is coming!

by Duckie1970 December 9, 2023

Duff

The shake at the bottom of a bag of drugs, including the seeds and stems in a bag of weed. Commonly used to describe the shake at the bottom of a bag of crystal meth.

Jeff: Hey, let me get a ball of that fire ice. Dan: All I have left is the duff, bro.

by jlthomas110880 November 25, 2020