by Ashkiba February 5, 2018

A DUFF is a D- Dumb U- Ugly F- Fat F- Friend basically the girl or boy that tries to cockblock you when you are trying to make a move on a girl or a boy
by Kiddericc March 22, 2021

Duff is a quiet man when you first meet him yet is incredibly observant and always listening. He takes his time in both thoughts and actions, but in the end is always ready to share the very best of himself. Duff is strong yet gentle, firm yet kind and mushy. If you are lucky enough to have a Duff in your life, then you are guaranteed a funny and generous confidante who will be by your side forever.
by Duckie1970 December 9, 2023

The shake at the bottom of a bag of drugs, including the seeds and stems in a bag of weed. Commonly used to describe the shake at the bottom of a bag of crystal meth.
by jlthomas110880 November 25, 2020

Desiganted Ugly Fat Friend. A common acronym used in male cliques. Used to refer to the girl that the "hot chicks" bring along to distract the "Wingman" (every male clique has one, his job is to intercept the DUFF.) so the ycan have the more desirable males of the group.
by TXwolfman817 February 24, 2009

dumb ugly or fat friend...
by NorCal Slanger March 27, 2017
