DUFF

The glue to a friendship. She/he will always support there friends no matter what. She can be a pain in the ass but everyone still loves her/him.

wow she is such a duff, i love her.

by ofiherjonfoqe[h November 5, 2018

DUFF

Deluxe Ultra Freaky Friend

man, that girl looks like a DUFF

by jdizzowizzo May 2, 2009

Duff

Beer you wish you could have but never will.

I'm craving some duff right now bro.

by lemonberrypie August 4, 2017

Duff

dumb ugly or fat friend...

Becky invited her duff so she doesnt get wasted and blows any willing cock within sucking distance

by NorCal Slanger March 27, 2017

Duff

Knock someone clean out

Imma duff his dumbass

by Hatehatty6 March 8, 2020

duff

dumb ugly fat friend

"cant she see she is the duff"

by go to bed April 19, 2017

Duff

The shake at the bottom of a bag of drugs, including the seeds and stems in a bag of weed. Commonly used to describe the shake at the bottom of a bag of crystal meth.

Jeff: Hey, let me get a ball of that fire ice. Dan: All I have left is the duff, bro.

by jlthomas110880 November 25, 2020