The stuff left on the bottom of your weed bags. All the stems, crystals, and leafs. Often used as a cheaper alternative to buds in baking. Though often mistaken as good, and used in joints and bowls. Known to be sold for as cheap as 30-40 dollars an ounce.
by fitzy_keegs January 13, 2017
Get the duffmug. 
by Bobz1992 February 7, 2014
Get the duff you inmug. Abv. For Designated Ugly Fat Friend. Usually the one person more approachable in a group and the one who is less attractive than all the others in the group. Sometimes a girl will approach a DUFF and start to flirt but after a while will begin to ask questions about another hotter member of the group.
Man #1: Dude, that's your job as the DUFF
Man#2: What did you just say to me?
Man#1: You're a DUFF, Designated Ugly Fat Friend.
Man#2: That's so messed up.
Man#2: What did you just say to me?
Man#1: You're a DUFF, Designated Ugly Fat Friend.
Man#2: That's so messed up.
by Sugary sweet April 7, 2017
Get the DUFFmug. Duff the DESIGNATED UGLY FAT FRIEND as a duff i would know its not fun ,sometimes u get ignored by ur friends and you feel left out
"I was a DUFF back in middle school."
by Vampie the queen October 20, 2021
Get the DUFFmug. by Fagboyslim88 January 13, 2017
Get the Duffmug. 