by Laurie-Bell February 1, 2009

The stuff left on the bottom of your weed bags. All the stems, crystals, and leafs. Often used as a cheaper alternative to buds in baking. Though often mistaken as good, and used in joints and bowls. Known to be sold for as cheap as 30-40 dollars an ounce.
by fitzy_keegs January 13, 2017

by Bobz1992 February 7, 2014

A cocktail consisting of equal parts Cynar, Campari, and gin with a splash of soda and an orange twist.
"Hey bartender, I'd like a drink that's neither too sweet not too bitter."
" How about a Duff?"
"Perfect!"
" How about a Duff?"
"Perfect!"
by megadope September 20, 2023

You just duffed out!
Man sorry i didn't hear you i was totally duffing out.
I really duffed out on that one
Man sorry i didn't hear you i was totally duffing out.
I really duffed out on that one
by Tazan August 22, 2011
