duff

(D)esginated (U)gly (F)at (F)riend
You are a duff
We have a duff in our friend group
by huoon October 15, 2021
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Duff

by gamerpeeps500 August 23, 2021
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Duff

That place on the human body (particularly the female body) where the body makes contact when sitting-down, i.e. the erogenous area of the butt.
I'll bet her duff is as sweet as candy!
by March 03, 2023
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Duff

The shake at the bottom of a bag of drugs, including the seeds and stems in a bag of weed. Commonly used to describe the shake at the bottom of a bag of crystal meth.
Jeff: Hey, let me get a ball of that fire ice. Dan: All I have left is the duff, bro.
by jlthomas110880 November 25, 2020
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duff

duff
Duff
Designated. Ugly. Fat. Friend
Ex. Britny is the duff in the group
Lisa and jen are hotties or the atravtive one and britney is ugly and fat compared to them
It can be guys (not alway ugly or fat) lets say they are freshmen and are like wingmen to upperclass men
*They are the ones who the girls go to ask if the jocks or alist guys in the group are single

The 2015 movie "Duff" is about a girl who is the duff in her group of friends at highschool who was unaware that she was the duff and was set oit to change it

"Duff " is not a positive thing to be called
by just a teen in 2k15 April 01, 2015
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