To take a shit in a very quick fashion. In and out of the stall in minutes, rarely involving excessive wiping.
I had to leave in the middle of that test for the bathroom, luckily it was a shit and run. I barely missed any time.
by Doctor Gels September 22, 2011

1- To stop drinking (usually an alcoholic beverage) or to start drinking more water
2- A Patrick Stump song that sounds like it was made in the mid 1980s.
2- A Patrick Stump song that sounds like it was made in the mid 1980s.
by Monica is ma nigga August 21, 2017

the process of turning on the sink to avoid public and private embarrassment for irregular bowel movements. In extreme cases running shower is also used.
by Tnix22 April 21, 2009

by makayla is bae December 1, 2016

When a group of almost gay guys get together on Lake Chicot to boat ride to different locations to pick up a playing card. At the end the winning hand gets to blow everyone.
Hey Parker, you wanna come over for the poker run this weekend? If we win I’ll let you have the prize!
by Goblin Dave June 17, 2018

When a group of stoner friends, one of whom has a prescription for medical marijuana, make a run to a legal cannabis dispensary, to obtain all sorts of cannabis goodies
Yo, I just burnt the last of my trees, let's make a club run to san francisco to get that good stuff
by Jdp420 October 6, 2008

when ur sitting with a bunch of people and you accidently let one rip. you get up and pretend to go do something else, but you are actually just running away from your fart so no one else knew you farted.
Hean: I'm gonna go get another drink.
Jay: eww, whats the smell? dude, did hean just fart-and-run?
Matt: Bah
Jay: eww, whats the smell? dude, did hean just fart-and-run?
Matt: Bah
by knobhead September 1, 2008
