as others have stated: something has angered, upset, annoyed, aroused you
this is more of a side note on origin - I suspect the phrase was a spontaneous misquote of a line from the Weezer song "Say It Ain't So" ("...flip on the telly/ wrestle with Jimmy...")
Uncle Jimmies Porn Emporium is a place of peace, strippers and ANAL. On the inside of this palace of PORN is just a great big wonderful rainbow of bondage, lesbians, etc. So come on down to Uncle Jimmies Porn Emporium, we do not condone eggs