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The submission finishing move of John Cena. This hold is known in professional wrestling as the Stepover Toehold Sleeper (STS) and innovated by Masahiro Chono. The wrestler performs a stepover toehold and wraps his arm around the neck of the opponent as in a sleeper hold.
John Cena made Batista tap out when he applied the STFU.
STFU by RGI December 27, 2008
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As of August 13th, 2009: International Suit Up Day.

STFU stands for "Suit the fuck up." It should be said when someone is not legendary (i.e not wearing a suit.) Should be said to anyone not wearing a suit on International Suit Up Day.
Person A (Wearing a suit) walks up to Person B (not wearing a suit)

Person A: "Dude STFU"
STFU by Syko/Aran August 13, 2009
Bill: STFU!

Jill: WHAT?!

Bill: *points to an angry unicorn* Shave it. It's furious
STFU by MusicEmo June 16, 2010
Stuff That's Fun Usually.
Canned goods and hitting little kids is STFU.
STFU by fruitsmakemehungry. August 21, 2009
Meaning: Shut The Fuck Up! used when instant messaging
Used in the IMing world: "You stupid bitch!....STFU"
STFU by Kirsti... yo. May 2, 2006
Acronym used for the phrase "Say, thanks for understanding."
"It's cool, bro."
"STFU"
Stfu by AwesomeTH October 10, 2006
Comes From Shut The Fuck Up
Guy 1: Why are you being a pussy today?
Guy 2: STFU!
STFU by Andrew Mister February 18, 2008