The Matthew Perry combo is when you get high on both ketamine and buprenorphine at the same time. (His previous heart/artery issues combined with this combination is what caused his death, not the combo itself). You will indeed get zooted off your ass if you take this combo, and is a phenomenal concoction of scientific wonders that will take you from the 3rd dimension to the 3.5th dimension.
Dude, my friends and I took the Matthew Perry combo last night and got fucking blasted. Those buprenorphine strips are weak as fuck though, so we had to double down. Weak ass fucking government opioids, next time we'll have to try the lil peep combo.
by Dfenley December 8, 2024
Get the Matthew Perry Combomug. by Lilandy May 27, 2023
Get the Perry madrinmug. 
The best man you will ever know. Smart , ambitious, and everything amazing. He will rock your world one day and make you smile.
by That drummer April 22, 2018
Get the Perrismug. by brettsterplow October 22, 2008
Get the Perry surprisemug. by Skl8888 December 8, 2020
Get the Mr Perrymug. A literary dumbass that thinks he can beat anyone with small muscles on both arms. Does math really well and also doing well in school, probably does wrestling but never had a serious game before. He probably wears glasses and sit on his ass all day playing children games ironically.
by Avonnned November 10, 2022
Get the casey perrymug.