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This is a catch phrase that originated in a TV ad in the late Eighties that featured super athlete extraordinaire Bo Jackson and rock'n'roll pioneer Bo Diddley (he's notorious for his famous box-shaped electric guitar). Basically, the term means that somebody doesn't know doodly squat.
The narrator says:
Bo knows football.
Bo knows baseball.
Bo knows weightlifting.
***********************
In the meantime, Bo Diddley cranks out the notes on his guitar.
Then he says:
Bo, you don't know diddley!
by I Saw U2 Live Twice October 2, 2007
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Now if you like a boy and you might be a girl or a boy and you are unsure how they feel a lot of people understand. Now the best way to deal with this is to get to know him better, get to know about his sexuality and how he deals with situations like in relationships. If he deals with them well and he flirts with you, you're in! But if he shows no interest in you or asks you for pics, drop him! He ain’t worth it!
Keliah: I like him but I don’t know how to tell him.
by Cutie Hyunjin September 30, 2020
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Phrase exclaimed by those working in fried chicken restaurants when they don't know what else to say

(Like, "Oh, sorry, my mistake)
**As witnessed at an actual Popeyes by T. Dale Shaw**

Elderly Woman: I called in an order for 300 pieces of chicken.

Popeyes Worker: (audible smack) Is dat fo here o to goes?

EW: Honey, I can't eat 300 pieces of chicken.

PW: Bitch, I don't know your life.
by dilbear February 25, 2005
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A response used when one person calls another one out on their bullshit.
"I don't think your life is as bad as you claim."
"You don't know, you've never been raped!"
by helrunr January 23, 2019
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I don't know

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What do you think it means? Whats that? You don't know? OH MY GOD! YOU JUST WORKED IT OT!
Why the hell are you reading definitions of "I Don't Know"?

Man... I don't know!
by Pimpage. April 2, 2005
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you don't know me!

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Jerry: Let's bring out the fat and ugly sluts!

*JERRY,JERRY, JERRY!*

Sluts come out screaming, "You don't know me! You don't know me!" while audience is booing with disgust.
by Carlito October 6, 2004
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When someone who you have met on several previous occasions acts like they don't know you when they see you in a different setting.
Susie: Hey, isn't that Joe from shipping who just walked past our table? He didn't even say, "Hello". I just talked to him earlier today!
Jenny: Yeah...he's got a case of the 'Don't Know Ya's.
by Likely March 3, 2010
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