It means what you don't know from what you wanna do in that moment what is happening..
Like for example!

When you have a problem and you don't know how to solve it:
I don't know what to do!
by Heysdj October 18, 2019
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Significant other is fed up or exhausted with the idea of you being around them.
Justin, you are getting to be too much and I'm confused about how I should handle you! You have made me mad/annoyed for the last time!!
("I don't know what I'm going to do with you!" is to be aggravated or annoyed by one's actions)
by November 19, 2022
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