Tom drank from 4pm to 6am. He then attended class the next morning. Around 2pm that day, Tom began feeling sick to his stomach. What he was experience was DOH.
Credit has been given to Homer Simpson for this word but I first heard it used back in Clifton High School in New Jersey back in 1968 by Ed S. and by a bunch of his school buddies with the added striking of the side of the head with the palm of the hand for emphasis. The meaning which has already been described by other posters is EXACTLY as it was back then. Sorry Homer...