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Street Slang Meanin' What's Goin' On?, Whazzup?, Whazz Up?, Wassup?, Sup?, Sup Witchu?, Sup Witcha?, What's Poppin'?, Whazz Poppin'?, What's Happenin'?, What's Hanninan?, How Are You Doin'?, How Yew Doin'?, How Are You?, How Yew?, How Are You Feelin'?, How Yew Feelin'?, What's Trendin'?, What's New With You?, What's New With Yew?, What's New Witchu? & What's New Witcha?
"Yo Killa Cam!! What's Up? Zero. Erstreet At Ever Soo Much At Ever Str8 Thuggin', Ever Str8 Stuntin' & Ever Livin' Life Fully." - Erstreet Harlem aka Harlem, Flea, Kiery Weiry & Freshley.
by Hzr February 24, 2022
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"Hey, what's up? I haven't heard from you in a while. How have things been?"
by Arminkshipper June 15, 2025
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what's up checkmark

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A reply made by youtube commenters when a verified youtuber leaves a comment on someone else's video
Youtuber: Great video, man!
Reply: what's up checkmark
by Redthetroll May 16, 2021
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What’s up G

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A slang way of saying hey or what you doin
Guy#1- “YO what’s up G”
Guy#2- “Nothin, just chillin
by Yo G from the hood May 12, 2019
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What's up, doc?

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A very famous quote from Bugs Bunny.
*Bugs Bunny gets out of his rabbit hole*

Elmer: Ahh! Wabbit!

Bugs: *chews a carrot* What's up, doc?

*Elmer freaks out*
by Keapon Laffin May 3, 2010
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A phrase used to ask about something odd, or what the point of something is. The word "that" can also be replaced with whatever noun the person is asking about. It is also common to inerject the word "fuck" into the phrase to express shock or discust.
What's up with the smirk?
Look at all those bags on the road. What's up with that?

Person1: What the fuck's up with your hand!?
Person2: Ahh! Why are you just standing there?! Take me to the fucking hospital!
by Cinymin86 November 16, 2009
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Used to say hello to any thing (person, dog, cat)
When you go over to your freinds house you say. Hey what's up skin.
by Arnold palmer 1 October 10, 2018
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