In porno, when a male actor is jerking off and he turns his hand "upside down" so that his thumb and forefinger are facing "down" toward his body and the palm is on top of the penis.
Peter North was yanking it and all of a sudden he turned his hand over and gave himself a reverse twisty.
by The Brains January 17, 2006

by Videorocker27 April 5, 2022

by Justinisgod December 9, 2014

Twisty fresh, sometimes known as Twisty Fresh Nips is used to describe freshly twisted nipples. Usually swollen,
Hard and sensitive .
Hard and sensitive .
by Kitten Key September 3, 2018

The act of sexual intercourse in the doggy style position in which you insert your thumb into the anus in a twisting motion, causing the recipient to "nay" like a horse.
by bsaks June 2, 2008

The movements one has after doing methamphetamine for days and days and days. The inability to sit in a chair without moving and flexing your body in peculiar ways.
Damn yo, that girl be doing the twisty flex!! Look at her, she's all pretzeled up in the corner picking at her face!! Chicken head!
by Astef May 3, 2015

A reference from Greys Anatomy. Can refer to someone who’s personally can come off as morose or can refer to someone going through a state of depression.
Are you and Christina in a dark and twisty place? Are you having the dark and twisties? - Derek Shepard - Greys Anatomy.
by GreysAnatomySuperfan June 25, 2022
