one who 'tweaks balls' as in one who uses the drug methamphetamine to get amped and then shakes around and talks non-stop.
I would have asked Mary to help me study for my test but she's such a tweaker --she couldn't sit still for more than 2 minutes so that's why I got a D+
by brandon December 3, 2002

a whore, a promiscuous female who engages in sexual activity with a lot of people who they have no relationship with.
by k_milly May 11, 2009

by Dzay June 22, 2007

by Bigmike13 March 29, 2022

A game residents of Terre Haute, Indiana play while driving through town. When you see someone you have to ask other people in the car, “Is that a tweaker?”. If you just guess yes, you are likely to be correct 75% of the time.
Turn on Locust Street, go a few blocks and when Donnie yells, “Is that a tweaker?” you’re in the right place.
What is that guy doing? Is that a tweaker?
What is that guy doing? Is that a tweaker?
by HairyGinger May 2, 2022

Someone using Crystal meth or ice are referred to as tweakers. They are commonly referred to as tweaking out as in a state of paranoia or moving and twitching profusely.
Look at the tweakers peeking out of the blinds.
Look ! That tweakers been down this aisle 17 times in 2 minutes.
Look ! That tweakers been down this aisle 17 times in 2 minutes.
by MizzuzKotzz×3 September 16, 2018

The reason high school security doesn’t go in the boys bathroom anymore, theres always atleast one of them.
Guy 1 “Guys, Jack’s a tweaker,”
Guy 2 “Yeah, we know,”
Guy 3 “He tried to choke me…”
Guy 2 “Okay, thats where we stop talking,”
Guy 2 “Yeah, we know,”
Guy 3 “He tried to choke me…”
Guy 2 “Okay, thats where we stop talking,”
by Veeve June 6, 2023
