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1. A man with very effeminate tendencies.

2. A guy who sucks at sports and/or isn't very strong emotionally.
1. Muhammad: Hey, Jack. Do you see Ryan over there? He's wearing a pink outfit, lipstick, eyeliner, and a wig. He's looking pretty Sweetie if you ask me.

2. Stan: Hey, Matt. I heard that the San Francisco Sweetie Niners finally won a game today. What a shock!

Matt: Yes. Very shocking. They are talentless and they don't have any heart or will to win.
Sweetie by OaklandRaider1983 August 24, 2021
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Term used by children and when speaking to children to refer to a single piece of candy, sweets
Please can I have a sweetie Grandma?
Grandma: What do you have in your mouth?
Granddaughter: a sweetie (shows tongue)
sweetie by 345rtg3dd July 24, 2021
Grandma to daughter:
What do you have in your mouth?
A sweetie
Can I have another sweetie Grammy?
sweetie by 345rtg3dd July 26, 2021
A word to call your lover or family members, mostly your children.
Will: I love you big sis!
Amelia: I love you too sweetie.
Sweetie by Urban Dictó May 30, 2022

Sweetie Belle 

Sweetie Belle is a unicorn, the sister of Rarity, and one of the three members of the Cutie Mark Crusaders in the series My Little Pony: Friendship is Magic.
Person 1: Have you heard of Sweetie Belle?
Person 2: Yeah! she's so cute *Squee*
Sweetie Belle by Twi-Twi December 15, 2013

Sweetie Wheatie 

There's nothing like the unconditional love and kisses from my sweetie wheatie.

sweetie pie 

Used as a term of endearment for someone you really like.
sweetie pie by Nayz April 21, 2005