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The term simply means sandwich. Originating in the southeastern states of the U.S. the term is representative of a pervasively localized regional dialect. Other cross-over examples from this dialect include: fifty-leven, ho, and stank.
An exhausted southern mother to her son:

Boy, leave me alone and go make you a may-nayse (mayonnaise) sammich.

N.B. other sammich varieties include: pork & bean, jelly, pork chop, egg, butter (i.e. margarine), sugar, and collard green.
sammich by sahmad01 July 23, 2008
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1. A sandwich that is extremely good.

2. What a Southerner calls a sandwich.
Honey-baked ham, roast beef, American AND Swiss cheese, tomatoes, lettuce, mayo, and mustard on French bread! Down here, we calls this a sammich!

"Ay, Cliff. Go up in thurr an' fix me a good sammich!"
~some guy from Texas
sammich by rock e. maivia February 22, 2007
Womens breast that have extremely long gross nipples.
Rob: I had Ms. Warren over last night.
Vik: Did you see her boobs this time?
Rob: Yeah she had some sammies!
Vik: Ew gross.
sammies by Phixxy January 25, 2011

SammieJO 

Referring to a person being fisted, anally or vaginally
That douchebag needs to be SammieJO'd
SammieJO by HardyHar December 15, 2008

Sammich Hands 

invented by Mike Reed. A fat bitches large hands, built for sandwich consumption
That bitch got sammich hands
Sammich Hands by Mykreed September 10, 2011
Sammi is a blonde green eyed beggar in Fortnite and always keeps up that same energy
She’s a beggar she definitely a sammi
Sammi by Beggars June 8, 2020

Nucko Sammich 

A term of endearment intended to bring a smile to those that continue to put up with your crap. Heard most often when the speaker is drunk or just lazy, or some combination of the two. Often confused with knuckle sammich or knuckle sandwich.
Hey sonny, why don't you bring me another beer or I'll ring up your friend Nucko Sammich.

Hey Nucko (Sammich), give your daddy a smooch or I'll introduce you to your namesake.
Nucko Sammich by Dr. Combs2 July 14, 2009