Expression of extreme fatigue, revulsion or similar burning desire to get the metaphorically exposed creepy-crawly critters out of the way as quickly as possible. A quote from Addams Family Values.
Oh, please, not more of these fanatical freaks! Not more vegetarian animal loving bomb experts! Who moved the rock?
Not more Aryan Nation types, oh please, who moved the rock?
when you do not understand a sentence a person has just spoken and the end word of the sentence sounds like pastor this phrase can be used in place of what or excuse me for comical enhancement.
Use of such statement in a Church or other Holy site could be considered blasphemous.