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whats up muthafucker 

It is a funny greeting to your friends.
Its like an insult but funnier.
Josh: Whats up man
Rick: Whats up muthafucker
whats up muthafucker by Anthony W. December 3, 2007

whats up bro

Bro is something you call a "mongrel" or a brother aka your friend... or your greatest enemy if you feel me. But a whatsup means WHAT IS NEW asking your friend/enemy what is new. If a friend, then you are actually asking "whats new" but if its an enemy this jargon is more or less used as a threat as in "whatsup bro, i will tear your spine out you disgusting maniac". People who DO use the term whatsup bro to their friends are deemed mentally and physically insane, and are fit for only one place in this godless world... the highest security mental intitution.
Alex: Whats up bro (to friend)
Carl: Um... not much.... yeah hello police? take this maniac away from me... STAT....

Alex: Whats up bro (to enemy)
Mark: Ahh a challenge.... finally an opponent worthy of my skills.....
whats up bro by CarlMarx November 24, 2013

whats up now

Said after coming upon someone who has done or said something earlier deserving of a beating, which could not be administered due to circumstance.
You were talking smack earlier with your friends.....Whats up now!!
whats up now by Brett A August 18, 2006

whats-up buddy 

A person you see at bars or parties that you always greet by either head-nod, handshake, or ever-popular "what up." However, the name of this person, along with all other personal information is unknown.
Guy: "Whats-up buddy"?
Whats-up buddy: "Hey bro"
(they walk right by eachother, no further communication)
Guy to his girlfriend: "Shit, I see that guy around all the time, but I don't have a clue what his name is"
whats-up buddy by doon November 14, 2006

whats up, whats goin on? 

used in the move "night at the roxbury' good way to greet anyone. especially women
Hey, whats up, whats goin on? So do you wanna make out or what?

whats up doc 

yo smoke weed and check this out
doctor-who-time-vortex-vr.pilots.bbcconnectedstudio.co.uk/

its trippy as fuck
whats up doc wanna do some blow?