Big Oof

Often expressing disappointment, but can also be used to express excitement over a current situation.

Sam: My mom is pregnant again
Bob: Sorry man I should have used protection
Drew: Big Oof

by SamsMom69 October 15, 2019

Big Oof

A phrase that is uttered by someone when they are in severe pain

“Big oof,” said Jack whilst in severe pain.

by chconly July 12, 2019

The Big Oof

Cancer, Usually transferred through memes

Yesterday i caught The Big Oof.

by Thanos March 4, 2019

Big Oof

A guy named Nick.

Nicholas is the legitimate definition of the term 'big oof'.

by imadethistotakethepiss November 27, 2018

Big Oof

When U don't have anything else to say but that one sound u keep on hearing when u die on ur christian ROBLOX server.

*Guy farts*
*Another Guy*: BIG OOF!

by Dictionary.com/;MC-REN-213-C^ January 8, 2019

big oof

An old as pedophile who plays roblox and is trying to snatch kids into their white van

Damn bro did you here that Mikey was Big Ooftoday by the guy 3 houses down

by effusive May 30, 2018

Big Oof Nibba

A particularly strong or annoying enemy in a singleplayer video game, typically a boss or other non-recurring entity.

Guy playing video games: "God, this boss has killed me like ten times now!!"

Guy's friend: "That's a Big Oof Nibba right there. Sorry, man"

by captconan June 4, 2018