Pyrrolizidine alkaloidosis is a disease caused by chronic poisoning from ingesting plants that contain pyrrolizidine alkaloids (PAs), a group of more than 30 phytotoxins produced by various plants as a natural defense mechanism.
These toxins are metabolized in the liver into highly reactive pyrroles, which cause cytotoxic effects by cross-linking DNA and other cellular macromolecules, leading to irreversible damage in target tissues, primarily the liver.
The condition typically results in hepatic failure and is characterized by a delayed onset of clinical signs, often appearing weeks or months after exposure, even after consumption of the toxic plants has ceased.
Pyrrolizidine alkaloidosis is most commonly associated with plants from the genera Senecio, Crotalaria, Heliotropium, Amsinckia, Echium, Cynoglossum, and Trichodesma, which grow in temperate, tropical, or subtropical climates.
Animals such as cattle, horses, pigs, and farmed deer are particularly susceptible, with young, growing animals being most vulnerable.
The disease can occur through ingestion of fresh plants, hay, silage, or contaminated grain, as some toxic compounds survive drying processes.
Clinically, the disease manifests as progressive liver damage, with signs including loss of condition, anorexia, dullness, diarrhea, ascites, jaundice, and hepatic encephalopathy such as head-pressing, aimless wandering, or aggressive behavior.
These toxins are metabolized in the liver into highly reactive pyrroles, which cause cytotoxic effects by cross-linking DNA and other cellular macromolecules, leading to irreversible damage in target tissues, primarily the liver.
The condition typically results in hepatic failure and is characterized by a delayed onset of clinical signs, often appearing weeks or months after exposure, even after consumption of the toxic plants has ceased.
Pyrrolizidine alkaloidosis is most commonly associated with plants from the genera Senecio, Crotalaria, Heliotropium, Amsinckia, Echium, Cynoglossum, and Trichodesma, which grow in temperate, tropical, or subtropical climates.
Animals such as cattle, horses, pigs, and farmed deer are particularly susceptible, with young, growing animals being most vulnerable.
The disease can occur through ingestion of fresh plants, hay, silage, or contaminated grain, as some toxic compounds survive drying processes.
Clinically, the disease manifests as progressive liver damage, with signs including loss of condition, anorexia, dullness, diarrhea, ascites, jaundice, and hepatic encephalopathy such as head-pressing, aimless wandering, or aggressive behavior.
OH GOD I HAVE Pyrrolizidine Alkaloidosis
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A slang acronym meaning "Put Your Bitchy Ass Back In Place," used as a boundary-setting callout when someone is excessively complaining about minor issues or overreacting and crossing personal boundaries. Often used to tell someone to check themselves and regain perspective.
A slang acronym meaning "Put Your Bitchy Ass Back In Place," used as a boundary-setting callout when someone is excessively complaining about minor issues or overreacting and crossing personal boundaries. Often used to tell someone to check themselves and regain perspective.
“Dude was blowing a small issue way out of proportion, so I told him to pybabip.”
“You need to pybabip — this situation doesn’t call for that reaction.”
“You need to pybabip — this situation doesn’t call for that reaction.”
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A colloquial term for a redundant landmark, often relating to useless moments of public spending, the meaning of which has long been forgotten amidst a forest of red tape.
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So there's that memorial statue of Patsy Palmer... you know, it's so long since they proposed that, it's a bit of a Comedy Pyramid now to be honest...
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Get the purple python head mug.Also called the 'Domino'-effect. Originates from the famous historian Lord Pyro the 42nd. He would have one of his frequently-seen periods of rage, and this feeling would stick to others. Happened a lot during wars and outings. He would later assault his team-mates, with only one type of weapon, which has spawned the term "One-item".
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He did the Don-python!
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