2-Chloromethylthiophene is used as an intermediate to 1-(2-thienyl)-2-Propanone.
In a 2-l. beaker surrounded by an ice-salt bath , and fitted with a mechanical stirrer and a thermometer, are placed 420 g. (392 ml., 5 moles) of thiophene and 200 ml. of concentrated hydrochloric acid. A rapid stream of hydrogen chloride is passed continuously into the mixture with vigorous stirring. When the temperature reaches 0°, 500 ml. of 37% formaldehyde solution is added at a rate that will permit the temperature to remain below 5°. The addition requires about 4 hours. When all the formaldehyde solution has been added, the mixture is extracted with three 500-ml. portions of ether. The ether extracts are combined, washed successively with water and saturated sodium bicarbonate solution, and then dried over anhydrous calcium chloride. The solvent is removed by distillation, and the product is distilled under reduced pressure through a 50-cm. fractionating column. The product boiling at 73–75°/17 mm. is collected. The yield is 257–267 g. (40–41%) of a colorless oily liquid.
In a 2-l. beaker surrounded by an ice-salt bath , and fitted with a mechanical stirrer and a thermometer, are placed 420 g. (392 ml., 5 moles) of thiophene and 200 ml. of concentrated hydrochloric acid. A rapid stream of hydrogen chloride is passed continuously into the mixture with vigorous stirring. When the temperature reaches 0°, 500 ml. of 37% formaldehyde solution is added at a rate that will permit the temperature to remain below 5°. The addition requires about 4 hours. When all the formaldehyde solution has been added, the mixture is extracted with three 500-ml. portions of ether. The ether extracts are combined, washed successively with water and saturated sodium bicarbonate solution, and then dried over anhydrous calcium chloride. The solvent is removed by distillation, and the product is distilled under reduced pressure through a 50-cm. fractionating column. The product boiling at 73–75°/17 mm. is collected. The yield is 257–267 g. (40–41%) of a colorless oily liquid.
I synthesized 2-chloromethylthiophene from thiophene, concentrated hydrochloric acid, and formaldehyde.
by CognitiveFuel January 21, 2024
Get the 2-chloromethylthiophene mug.the quickest way to blow up
by raybeez April 8, 2022
Get the arrogant twitch of potassium chloride mug.Related Words
Chlonr • chlorine • chloroform • chloris • chlorophyll • chlodrew • chlono • chlora • Chloraseptic • Chlore Fils-Aime
by madelynnxoxo August 29, 2022
Get the guar hydroxypropyltrimonium chloride mug.A phrase used by people who have never smelt chloroform and/or those who don't know how chloroform actually works. Supposedly the person will pass out after sniffing a rag soaked in chloroform like in the movies, but in reality they would think it's some kind of cleaning fluid with fragrance if it hasn't evaporated in less than a minute.
He asked "does this smell like chloroform" before handing me a rag that seemed to be wet. I said "yes, that's trichloroethylene and it smells like chloroform"
by vaegsoojumus September 25, 2023
Get the Does this smell like chloroform mug.