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Chocolate cupcake with red frosting 

A prolapsed anus
When the anus protrudes out of ones backside, it resembles a cupcake with red frosting, but that’s where the poop comes from, hence chocolate cupcake with red frosting.

georgetown cupcake 

A place where pretentious, self-important females go to feel fancy by waiting in an hour-long line to purchase mediocre, overpriced cupcakes.
Young twenty-something: "I MUST go to Georgetown Cupcake today! After all, I've been rotting my life going to sorority parties and overspending on frivolous crap, so what harm could it do?"
georgetown cupcake by ossrey February 18, 2011

cum cupcake 

A snack made specifically for giagantic whores who crave penis milk. The recipe is pretty simple: Get a cupcake, then cum on it. The result is that you have a cum cupcake. Enjoy. Don't microwave.
Julie was feeling pretty hungry and that bitch already ate all my food so I decided to fix her a nice little cum cupcake and watch her eat that shit. I got bored after that and went to watch some food network and beat off.
cum cupcake by JeffT1085 May 24, 2006

cupcake hands 

Don't touch me with them cupcake hands
cupcake hands by Shaolin Allen February 28, 2007

Cupcaker 

someone who is cutesy and flirty with everyone, male or female.

see: cupcaking
i know this girl, shes a total cupcaker.
Cupcaker by c-raee December 8, 2007

Twilight Cupcakes 

When two girls on their rag get in the scissor position, and vigorously convulse whilst screaming Edwards name.
"Dude, those bitches are crazy. I bet they left the theater to make some Twilight Cupcakes."