Hunter of the DUFF (Designated Ugly Fat Friend), not to be confused with the Milf Hunter. The Duff Hunter is solely after big game and nothing else, like a cheetah in the Serengeti taking down a wounded gazelle.
by The Duff Hunter February 20, 2015

The bassist for guns n' roses for all of their albums except chinese democracy. He is now with Slash in Velvet Revolver. He was a good bassist, and is also a realy nice guy. He now has had to give up the rock star lifestyle since he's married with 2 kids, but he still rocks when he's playing music. never actualy was kicked out of guns n roses- he and Slash, the only original members left, kicked Axl Rose and all the replacement members out in '98. Axl then sued them for the rights to the name, won, and Duff and Slash formed Velvet Revolver. Like the other gunners, duff had trouble with drugs and booze. he now has quit drinking, after his pancreas burst and he learned that any more alchohol would kill him. He's not much of a partier any more, but he's still a realy cool guy.
by king of canada September 9, 2006

A brand of beer drank by Homer Simpson and his friends in popular Television show "The Simpsons". It is the only drink that Moe Syzlack stocks at his tavern, Moe's Tavern.
by Tuddy September 10, 2007

A short person of non-hispanic decent, often acts in an irrational manor. A raging homophobe/Bigot, ultra conservative;
Fights to end women's suffrage, disagrees with abortion rights. P Duff wishes to go back to the good ole days of 1843. P Duff just wants everyone to go back to where they came from.
Fights to end women's suffrage, disagrees with abortion rights. P Duff wishes to go back to the good ole days of 1843. P Duff just wants everyone to go back to where they came from.
by IHatePaigeBuffy May 22, 2023

It was very embarrssing for Kevin when he got Peggy up the duff, but it served him right for trying to save money by using a flak jacket.
by Dunky Oggins December 7, 2003

a drink spiked with roofies and viagra used by the DUFF(designated ugly fat friend) in order to get laid.
"dude dont drink that its a DUFF cocktail." "i woke up with a headace and a raging boner next to a WHALE, It must have been the Duff Cocktail."
by [THE]fixer5588 March 15, 2010
