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Screwed the pooch 

To have sex with a dog.
Jize Layo screwed the pooch for his new film, "Jize Layo does a dachsund IV"
Screwed the pooch by Jose Loya September 13, 2005

Screwed the Pooch 

When you really screw up. Mess things up royally.
He screwed the pooch when he wrecked his truck.
Screwed the Pooch by Georgia Rooster February 27, 2019

screwed the pooch 

Screwing the pooch is a nonsensical action that is being done while a major fuck up is occuring or has occured.
Management have screwed the pooch while the competition gained the upperhand.
screwed the pooch by ANTZILLA July 13, 2014

Screwed The Pooch 

You've fucked up so bad the only real way of describing it is as though you have fucked a dog and have to explain it to your parents.
Morty: awe geez I really screwed the pooch on that one.

Rick: nice going morty, snowball will definitely neuter you after that stunt.
Screwed The Pooch by The_law21 November 5, 2019

screwed the pooch and knocked it up 

To have made a massive, catastrophic blunder. An extension of the more common "screwed the pooch," which adds a more severe consequence to the metaphorical action.
Since invading Iraq, President Bush and his advisors have really screwed the pooch and knocked it up.