S2S 

smiles to self , short hand aka computer abbreviations

Rarely do I lol but often I s2s.
lol rotflmao lmao brb btw

S2S by gap918 May 14, 2013

S2S 

Sister 2 Sister

"sis, I got you...S2S forever".

"Unbreakable bonds"

S2S by LadyJLauren August 26, 2021

S2S 

Skin to skin. A loose term for the act of having sex with someone without contraceptives. So S2S is a sleek way of saying the same thing abbreviated.

I want us to go S2S during Netflix and Chill.

S2S by Mbuba April 21, 2023