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Little Sister

A woman who is officially affiliated with a fraternity. Little Sisters are usually given the fraternity's letters to wear after a sort of initiation, but they don't undergo a Pledge period and have limited rights and privileges within the frat. They are not considered to have equal standing with the Brothers and don't participate in rituals or attend meetings.Usually long time friends of the guys in the frat and/or the serious girlfriend of a Brother, a Little Sisters provide support to the fraternity. They assist in Rush events, bake cookies, and generally make the guys look good.
After two years of baking brownies and cleaning up after the guys Kari was made a Little Sister of the fraternity.
by Oh Donna May 21, 2008
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Little Sister Syndrome

In which a guy tells a girl who's obviously got the hots for him that he "thinks of her as a sister" or "she's a little sister to him," so as to blow her off lightly.
This is sometimes considered offensive and rarely considered an actual compliment, as the girl usually knows that this means that he doesn't see her as date-able.
Used frequently on friendly yet ugly girls.
Sam: Oh, Bertha, you're so cute!
Bertha: Really, you think so?
Sam: Oh yea; you're like a little sister to me!"
Bertha: Oh...

*later*

Sally: Sam complimented you?
Bertha: Yea, but then he ruined it via little sister syndrome.
Sally: Jerk.
by andi844 August 22, 2007
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Little Sister

Little Sisters are genetically enhanced female children between the ages of about 4 and 7 who roam the halls of Rapture looking for ADAM. When they come across a body containing ADAM (an "Angel") they stop and using their syringe needles they extract the ADAM from the body. They then move on to the next body, sipping the blood/ADAM mix in their syringe needles. Once the blood/ADAM mix enters their bodies the ADAM is separated by the ADAM slugs living like parasites inside of them.
Now should you get your hands on a Little Sister (that is if you can get past their protectors the Big Daddies whom they refer to as Mr. Bubbles or Mr. B), you have a few options. You can save the little sister by killing the slug in her. This will turn her into a normal little girl, you will get whatever ADAM she has on her and she will be forever in your debt which can come to an advantage later. The second option is you can harvest her which will result in a maximum ADAM gain. This can lead to more plasmids and will make it easier for you to survive. She will not survive the process however.

Your final option can only be achieved if you are also a Big Daddy. You can adopt her and act as her protector. Bring her to the "Angels" and keep her safe while she gathers ADAM. She will then give you a portion of her ADAM and after two gathers you can choose to save or harvest.
Jack approached the crying Little Sister slowly, Tenenbaum's and Atlas' voices echoing in his head.

Hurry Mr. B! Angels don't wait for slowpokes.

I can see angels!

Get him Mr. B!
by Grace Holloway March 1, 2010
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little sister jeans

jeans worn by men that look like their little sisters jeans.
why do you think pete wentz wears little sister jeans?
by hotel room service August 27, 2009
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little sister syndrome

When the younger sister of an older sister is more attractive than the latter
Laura is hot but her sister Rachael is infected with little sister syndrome.
by 4pumpwonderchump July 15, 2009
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Little sister

Little sister sucks the attention out of anything.
by Pepe the fwoooog July 10, 2019
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little sister

Girls who hang around a fraternity in hopes of finding a boyfriend/husband. Usually they find neither but end up geting fucked by numeroius members of the fraternity.
I hope this semester we get some new little sisters!
by yo mama September 16, 2003
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